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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Acute Coronary Syndrome I: Introduction01:30

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Restless Leg Syndrome and Night Terrors01:27

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Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
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Acute Coronary Syndrome V: Nursing Management01:26

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Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Gorlin-Goltz syndrome.

V Bartoš, M Kullová, K Adamicová

    Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
    |April 19, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Gorlin-Goltz syndrome, a rare inherited cancer predisposition disorder, presents with diverse symptoms. Early diagnosis and lifelong interdisciplinary care are crucial for managing this serious condition.

    Keywords:
    Gorlin-Goltz syndromebasal cell carcinomaodontogenic cysts

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    Area of Science:

    • Genetics and Oncology
    • Dermatology
    • Oral and Maxillofacial Surgery

    Background:

    • Gorlin-Goltz syndrome is an autosomal dominant disorder linked to increased cancer risk.
    • Clinical manifestations are varied and often appear later in life.

    Observation:

    • A 34-year-old male presented with multiple basal cell carcinomas and jaw/mandible odontogenic keratocysts.
    • Additional findings included macrocephaly, hypertelorism, and vertebral abnormalities.

    Findings:

    • Histological examination confirmed 11 basal cell carcinomas.
    • The patient's comprehensive clinical and pathological findings met the diagnostic criteria for Gorlin-Goltz syndrome.

    Implications:

    • Early diagnosis and treatment are critical for improving prognosis in Gorlin-Goltz syndrome.
    • Lifelong, multidisciplinary medical surveillance is essential for patients diagnosed with this syndrome.