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Cardiotoxicity due to targeted anticancer agents: a growing challenge
1Department of Medicine, Hematology Oncology Division, University of Florida, 1600 SW Archer Road, Gainesville, 32608, FL, USA.
Therapeutic Advances in Cardiovascular Disease
|April 19, 2019
Summary
Targeted anticancer agents can cause cardiotoxicity, leading to the growth of cardio-oncology. More research is needed to understand and predict these cardiovascular complications (CVCs) for better patient survival.
Area of Science:
- Cardio-oncology
- Oncology
- Cardiology
Background:
- Targeted anticancer therapies present unique challenges due to their cardiotoxic potential.
- Cardiovascular complications (CVCs) vary significantly among agents, complicating prediction and screening.
- The mechanisms, risk factors, and natural history of these toxicities remain poorly understood.
Discussion:
- The field of cardio-oncology is rapidly evolving to address the cardiovascular risks associated with cancer treatments.
- Developing predictive screening tests for CVCs is difficult due to inter-agent variability.
- Unanticipated toxicities can negatively impact overall survival in cancer patients.
Key Insights:
- Understanding the mechanisms and risk factors for CVCs is crucial.
- Biomarker identification is essential for developing effective monitoring strategies.
- Early detection of CVCs can improve patient outcomes and survival.
Outlook:
- Further research is imperative to address the unmet needs in cardio-oncology.
- Standardized monitoring protocols are required to manage CVCs effectively.
- Continued investigation will refine risk stratification and personalized treatment approaches.
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