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Cardiotoxicity due to targeted anticancer agents: a growing challenge

Chintan P Shah1, Jan S Moreb2

  • 1Department of Medicine, Hematology Oncology Division, University of Florida, 1600 SW Archer Road, Gainesville, 32608, FL, USA.

Therapeutic Advances in Cardiovascular Disease
|April 19, 2019
PubMed

Insights

Targeted anticancer agents can cause cardiotoxicity, leading to the growth of cardio-oncology. More research is needed to understand and predict these cardiovascular complications (CVCs) for better patient survival.

Area of Science:

  • Cardio-oncology
  • Oncology
  • Cardiology

Background:

  • Targeted anticancer therapies present unique challenges due to their cardiotoxic potential.
  • Cardiovascular complications (CVCs) vary significantly among agents, complicating prediction and screening.
  • The mechanisms, risk factors, and natural history of these toxicities remain poorly understood.

Discussion:

  • The field of cardio-oncology is rapidly evolving to address the cardiovascular risks associated with cancer treatments.
  • Developing predictive screening tests for CVCs is difficult due to inter-agent variability.
  • Unanticipated toxicities can negatively impact overall survival in cancer patients.

Key Insights:

  • Understanding the mechanisms and risk factors for CVCs is crucial.
  • Biomarker identification is essential for developing effective monitoring strategies.
  • Early detection of CVCs can improve patient outcomes and survival.

Outlook:

  • Further research is imperative to address the unmet needs in cardio-oncology.
  • Standardized monitoring protocols are required to manage CVCs effectively.
  • Continued investigation will refine risk stratification and personalized treatment approaches.
Keywords:
cancercardiotoxicitycardiovascular toxicitytargeted agentstherapy

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