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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
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Characterization of Infections with Vancomycin-Intermediate Staphylococcus aureus (VISA) and Staphylococcus aureus

Jung Wan Park1,2, Hyungmin Lee1, Jung Wook Kim3

  • 1Department of Healthcare-Associated Infection Control, Korea Centers for Disease Control and Prevention, Cheongju, South Korea.

Scientific Reports
|April 19, 2019
PubMed

Insights

Staphylococcus aureus with reduced vancomycin susceptibility (SARVS), including vancomycin-intermediate S. aureus (VISA), was found in South Korea. No vancomycin-resistant S. aureus (VRSA) was detected, with SARVS linked to indwelling devices and prior procedures.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health Surveillance

Background:

  • Antimicrobial resistance is a growing global health concern.
  • Staphylococcus aureus, particularly methicillin-resistant strains, poses a significant threat.
  • Monitoring reduced susceptibility to last-resort antibiotics like vancomycin is crucial.

Purpose of the Study:

  • To characterize infections caused by Staphylococcus aureus with reduced vancomycin susceptibility (SARVS) in South Korea.
  • To identify the prevalence of vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA).
  • To determine risk factors associated with SARVS infections.

Main Methods:

  • Analysis of data from a national sentinel surveillance system (2014-2016).
  • Identification and susceptibility testing of Staphylococcus aureus isolates.
  • Review of medical records for patient demographics and clinical history.

Main Results:

  • 66 cases of SA-RVS were reported; 14 isolates (21.2%) were VISA.
  • No vancomycin-resistant S. aureus (VRSA) was detected.
  • SA-RVS was associated with indwelling devices (81.8%), recent surgery (84.8%), ICU admission (68.2%), and prior vancomycin or MRSA exposure.

Conclusions:

  • SA-RVS, including VISA, is present in South Korea, primarily in high-risk patients.
  • The absence of VRSA is a positive finding, but continued surveillance is essential.
  • Risk factors highlight the need for infection control measures in vulnerable patient populations.

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