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Related Concept Videos

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Comparison of multi-tissue aging between human and mouse.

Jujuan Zhuang1, Lijun Zhang1, Shuang Dai1

  • 1School of Science, Dalian Maritime University, Dalian, Liaoning, 116026, P. R. China.

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|April 19, 2019
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This study compares gene expression in human and mouse tissues to understand aging. It found significant molecular similarities between species, particularly in brain tissues, advancing aging research.

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Area of Science:

  • Gerontology
  • Molecular Biology
  • Comparative Genomics

Background:

  • The aging population necessitates research into the biological basis and molecular mechanisms of aging.
  • Aging is linked to organ dysfunction, age-related diseases (metabolic, nervous, cardiovascular), and cancer.
  • Understanding molecular parallels between human and mouse aging is crucial for translational research.

Purpose of the Study:

  • To systematically assess the relationship between human and mouse aging at the molecular level.
  • To compare age-related gene expression patterns across multiple tissues in humans and mice.
  • To identify conserved molecular signatures of aging between species.

Main Methods:

  • Comparative analysis of age-related gene expression datasets from 18 human and mouse tissues.
  • Functional enrichment analysis of identified age-related genes.
  • Crosswise comparison of homologous age-related genes between human and mouse tissues, with a focus on brain regions.

Main Results:

  • Identified 9 significantly correlated tissue pairs between human and mouse aging.
  • Functional analysis revealed conserved aging-related terms in both species.
  • Human Brain Cortex and Hippocampus showed significant correlation, mirrored in mouse.
  • The gene GFAP was identified as age-related in both human and mouse brain tissues.

Conclusions:

  • Significant molecular similarities exist in aging processes between humans and mice across multiple tissues.
  • Brain tissues, specifically the cortex and hippocampus, exhibit conserved age-related gene expression patterns.
  • This comparative approach provides a foundation for understanding conserved aging mechanisms and developing targeted interventions.