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NDV-3A vaccination prevents C. albicans colonization of jugular vein catheters in mice

Abdullah Alqarihi1, Shakti Singh1, John E Edwards1,2

  • 1Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

Scientific Reports
|April 19, 2019
PubMed

Insights

A novel fungal vaccine, NDV-3A, demonstrated protection against recurrent vulvovaginal candidiasis in women. Preclinical studies show it prevents Candida albicans infections and biofilm formation, suggesting potential for medical devices.

Area of Science:

  • Mycology
  • Immunology
  • Vaccinology

Background:

  • Recurrent vulvovaginal candidiasis remains a clinical challenge.
  • Candida albicans employs Als3 protein for adhesion and invasion.
  • Novel immunotherapies are needed for fungal infections.

Purpose of the Study:

  • To evaluate the preclinical efficacy of NDV-3A, a fungal vaccine candidate.
  • To investigate the mechanism of action of anti-rAls3p-N antibodies.
  • To assess NDV-3A's potential in preventing device-associated candidiasis.

Main Methods:

  • Active immunization of mice with NDV-3A.
  • Measurement of anti-rAls3p-N antibody titers.
  • In vitro assays for C. albicans adhesion, invasion, and biofilm formation.
  • In vivo studies assessing fungal dissemination and catheter colonization.

Main Results:

  • NDV-3A induced high titers of neutralizing anti-rAls3p-N antibodies.
  • Antibodies inhibited C. albicans adhesion, invasion, and biofilm dispersal.
  • Vaccination prevented systemic C. albicans dissemination and catheter colonization in mice.

Conclusions:

  • NDV-3A elicits protective immunity against C. albicans.
  • The vaccine's mechanism involves antibodies targeting rAls3p-N.
  • NDV-3A shows promise as an immunotherapeutic for preventing candidiasis and device-related infections.

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