Related Experiment Video
Updated: Jan 26, 2026

08:57
Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
Published on: April 4, 2012
24.3K
[Spinal cord stimulation for non-reconstructable chronic ritical limb ischemiae: a case report]
1Department of Vascular Surgery, Peking University People's Hospital, Beijing 100044, China.
Summary
Spinal cord stimulation offers pain relief and limb salvage for critical limb ischemia patients unsuitable for surgery. This minimally invasive treatment shows significant effectiveness in improving quality of life.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Pain Management
Background:
- Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis, leading to critical limb ischemia (CLI) with severe pain and ulcers.
- Surgical revascularization is standard for CLI, but comorbidities often contraindicate it, necessitating alternative treatments.
- Spinal cord stimulation (SCS) is a minimally invasive option for pain relief and limb salvage in CLI patients.
Observation:
- A case of chronic CLI with foot gangrene, diagnosed with Burger disease and multiple comorbidities, was treated with SCS.
- Computed tomography angiography revealed extensive arterial occlusions precluding traditional revascularization.
- A temporary SCS device was implanted, followed by a permanent one after positive initial results.
Findings:
- The patient experienced significant pain relief and a 20% improvement in transcutaneous oxygen pressure after SCS.
- Long-term follow-up showed pain stabilization with minimal medication, indicating SCS effectiveness.
- This case represents the first application of SCS for CLI in China.
Implications:
- SCS is a viable and effective treatment for pain control and limb salvage in patients with non-reconstructable CLI.
- SCS improves quality of life for CLI patients who are not candidates for surgical revascularization.
- Further research is needed to evaluate the long-term limb salvage outcomes of SCS in CLI.
Related Concept Videos
Spinal Cord
1.7K
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
1.7K
The Spinal Cord
31.6K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
31.6K
Spinal Cord: Information Processing
3.3K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
3.3K
Spinal Cord: Gross Anatomy
5.5K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
5.5K
Spinal Cord: Cross-sectional Anatomy
4.5K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
4.5K
Critical Region, Critical Values and Significance Level
13.3K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
13.3K

