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Nivolumab and immune-mediated colitis
Heather Walker1, Paul Brennan1,2, Maximillian Groome2
1Ninewells Hospital and Medical School, University of Dundee and NHS Tayside Dundee UK.
Nivolumab can cause immune-mediated colitis after treatment cessation. Higher-dose methylprednisolone rapidly resolved symptoms, reducing hospitalization compared to standard lower doses.
Area of Science:
- Oncology
- Immunology
- Gastroenterology
Background:
- Nivolumab, an immune checkpoint inhibitor, is linked to immune-mediated adverse events.
- Immune-mediated colitis can occur even after nivolumab treatment discontinuation.
Observation:
- A patient presented with immune-mediated colitis following nivolumab discontinuation.
- Standard treatment involves lower doses of methylprednisolone.
Findings:
- Higher-dose methylprednisolone therapy led to faster symptom resolution.
- This approach potentially minimizes patient hospitalization duration.
Implications:
- Higher-dose corticosteroids may be a viable option for managing nivolumab-induced colitis.
- Optimized treatment protocols can improve patient outcomes and reduce healthcare resource utilization.
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