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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Targeted therapy in cervical cancer.

Chakor Vora1, Sudeep Gupta1

  • 1Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

ESMO Open
|April 19, 2019
PubMed
Summary

Cervical cancer treatment has seen limited progress, with bevacizumab as a recent addition for advanced stages. Emerging therapies like immune checkpoint inhibitors offer new hope for cervical cancer patients.

Area of Science:

  • Gynecologic Oncology
  • Medical Oncology
  • Translational Cancer Research

Background:

  • Cervical cancer remains a significant global health issue, particularly in developing regions, often presenting at advanced stages.
  • Current treatment paradigms for recurrent/metastatic cervical cancer are limited, with bevacizumab added to chemotherapy representing the sole recent advancement.
  • Outcomes for locally advanced cervical cancer have stagnated following initial improvements from chemoradiation therapy.

Purpose of the Study:

  • To review recent advancements in understanding cervical cancer molecular aberrations.
  • To discuss the emerging therapeutic modalities for cervical cancer treatment.
  • To evaluate the potential utility of novel approaches including immune checkpoint inhibitors, vaccines, and antibody-drug conjugates.

Main Methods:

Keywords:
Cervical cancertargeted therapy

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  • Literature review of recent clinical trials and preclinical studies.
  • Analysis of data on molecular targets and therapeutic strategies in cervical cancer.
  • Synthesis of information on emerging treatments and their potential clinical application.

Main Results:

  • Bevacizumab combined with chemotherapy is the current standard for recurrent/metastatic disease.
  • Significant progress in understanding cervical cancer's molecular landscape is paving the way for targeted therapies.
  • Several novel therapeutic avenues, including immunotherapy and antibody-drug conjugates, are under investigation.

Conclusions:

  • Despite progress, novel therapeutic strategies are urgently needed for cervical cancer.
  • Emerging modalities like immune checkpoint inhibitors and antibody-drug conjugates show promise for improving patient outcomes.
  • Further research and clinical trials are essential to validate and integrate these new approaches into cervical cancer treatment.