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Related Experiment Video

Updated: Jan 26, 2026

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
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Reducing red blood cell folate testing: a case study in utilisation management.

Ola Ismail1, Ian Chin-Yee2,3, Alan Gob3

  • 1Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

BMJ Open Quality
|April 19, 2019
PubMed
Summary
This summary is machine-generated.

Mandatory folic acid fortification has made folate deficiency rare. A quality improvement initiative successfully reduced red blood cell folate testing by implementing physician education and requiring biochemist approval, significantly cutting unnecessary tests.

Keywords:
implementation sciencelaboratory medicinequality improvement

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Area of Science:

  • Clinical Chemistry
  • Public Health
  • Laboratory Medicine

Background:

  • Mandatory folic acid fortification of wheat flour in Canada since 1998 has led to a significant decrease in folate deficiency.
  • Previous testing at London Health Sciences Centre (LHSC)/St. Joseph's Healthcare London (SJHC) revealed no folate deficiency cases despite numerous red blood cell (RBC) folate tests.
  • High test volumes indicated potential overutilization of RBC folate testing.

Purpose of the Study:

  • To implement a quality improvement initiative aimed at reducing unnecessary RBC folate testing at LHSC/SJHC.
  • To assess the impact of physician education and a new testing protocol on RBC folate test volumes.

Main Methods:

  • Retrospective review of RBC folate tests performed over an 18-month period.
  • Physician outreach via educational emails to high-volume prescribers.
  • Discontinuation of in-house RBC folate testing, requiring biochemist approval for external testing via a computerised physician order entry system pop-up.

Main Results:

  • Initial physician education email resulted in a 24% decrease in average monthly test volume.
  • Subsequent discontinuation of in-house testing and implementation of a biochemist approval process led to a further 74% reduction in test volume.
  • In the 10 months post-discontinuation, only 39 RBC folate tests were performed, with no deficiencies detected.

Conclusions:

  • The quality improvement initiative effectively reduced unnecessary RBC folate test orders.
  • Physician education played a role, but restricting access through biochemist approval was the most impactful measure.
  • This approach demonstrates a successful strategy for optimizing laboratory test utilization in response to public health changes.