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Published on: March 15, 2021
Cell factory engineering for improved production of natural products
1BioInnovation Institure, Ole Maaløes Vej 3, DK2200 Copenhagen, Denmark and Department of Biology and Biological Engineering, Chalmers University of Technology, SE41296 Gothenburg, Sweden and Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK2800 Kgs. Lyngby, Denmark. jni@novo.dk.
Abstract:
Natural product biosynthesis is inherently linked with the primary metabolism in terms of providing precursors and co-factors. Thus, even though it is important to improve the performance of natural product biosynthetic enzymes in building efficient cell factories, it is equally important to engineer the central carbon metabolism, such that this is adjusted to meet the biosynthetic demand of the desired product.
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