Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sustainable Development01:43

Sustainable Development

14.8K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
14.8K
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.0K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.0K
Language Development01:22

Language Development

879
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
879
Photoluminescence: Applications01:14

Photoluminescence: Applications

1.0K
Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
1.0K
Radiation: Applications01:17

Radiation: Applications

1.7K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
1.7K
Development of the Heart01:27

Development of the Heart

2.3K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cholecystectomy vs Endoscopic Retrograde Cholangiopancreatography or No Intervention After Gallstone-Related Acute Pancreatitis.

JAMA surgery·2026
Same author

The Farooq, not the Lerner, grading system predicts disease-specific and overall survival in duodenal graft-versus-host disease.

Human pathology·2026
Same author

Liquorice alters adipocyte-breast cancer cell crosstalk by modulating oxidative stress and suppressing aromatase and renin-angiotensin signalling.

International journal of food sciences and nutrition·2026
Same author

The Influence of Lifestyle on Cognitive Function and Quality of Life in People with Dementia.

Neuropsychiatric disease and treatment·2026
Same author

Clinical application of base editing for treating β-thalassaemia.

Nature·2026
Same author

Establishing an atherosclerosis diagnostic model based on WGCNA and machine learning algorithms with key genes in cholesterol metabolism and ferroptosis, and revealing the regulatory role of HMOX1 in cellular ferroptosis.

Frontiers in cardiovascular medicine·2026
Same journal

Evaluation of Prime Editing Efficiency in Human Immortalized MSC-TERT Cells with Osteogenic Potential for Modeling <i>FGFR2</i>-Linked Craniosynostosis.

The CRISPR journal·2026
Same journal

Induction of SpCas9-Directed Immune Responses Using Lipid Nanoparticles and Identification of SpCas9-Derived T Cell Epitopes in C57BL/6 Mice.

The CRISPR journal·2026
Same journal

Advice from the CRISPR Whisperer.

The CRISPR journal·2026
Same journal

CRISPR Learns to Read the Epigenome.

The CRISPR journal·2026
Same journal

Increasing the Effective Gene Drive Homing Rate by Targeting the Haploinsufficient Spermatogenesis Gene <i>Klhl10</i>.

The CRISPR journal·2026
Same journal

<i>Corrigendum to:</i> "Subtypes of Type I-E CRISPR-Cas Systems Distribution in Human <i>Escherichia coli</i> Isolates from China".

The CRISPR journal·2026
See all related articles

Related Experiment Video

Updated: Jan 26, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
09:22

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

6.0K

Development and Application of Base Editors.

Bei Yang1, Li Yang2,3, Jia Chen3,4

  • 11 Shanghai Institute for Advanced Immunochemical Studies and Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.

The CRISPR Journal
|April 19, 2019
PubMed
Summary
This summary is machine-generated.

Base editing, a precise gene editing technology, uses nucleobase deaminases with Cas9 or Cpf1 to make targeted DNA changes. This powerful tool has shown high efficiency in animals, plants, and bacteria for single-base substitutions.

More Related Videos

Design and Development of Aptamer&#8211;Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications
08:23

Design and Development of Aptamer–Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications

Published on: June 23, 2016

12.7K
Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

5.7K

Related Experiment Videos

Last Updated: Jan 26, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
09:22

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

6.0K
Design and Development of Aptamer&#8211;Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications
08:23

Design and Development of Aptamer–Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications

Published on: June 23, 2016

12.7K
Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

5.7K

Area of Science:

  • Molecular Biology
  • Genetics
  • Biotechnology

Background:

  • Base editing is an innovative gene editing technique.
  • It enables precise modifications to DNA sequences.
  • Recent advancements have expanded its utility.

Purpose of the Study:

  • To review the latest developments in base editing technology.
  • To summarize the applications of base editors across various organisms.
  • To discuss future prospects and challenges in the field.

Main Methods:

  • Combining nucleobase deaminases with CRISPR-associated enzymes (Cas9 or Cpf1).
  • Developing novel base editor systems for targeted DNA modifications.
  • Reviewing published literature on base editor applications.

Main Results:

  • Several base editors have been engineered for precise base conversions.
  • High efficiency of base editing demonstrated in animals, plants, and bacteria.
  • Successful induction of single-base substitutions at targeted genomic locations.

Conclusions:

  • Base editing represents a significant advancement in precise gene editing.
  • Its successful application across diverse species highlights its potential.
  • Further research will likely expand the capabilities and applications of base editing.