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Related Concept Videos

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Related Experiment Video

Updated: Jan 26, 2026

Isolation of Myeloid Dendritic Cells and Epithelial Cells from Human Thymus
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Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE): A Case Report.

Cyrus L Matheson1, Geoffrey K Blair2, Jonathan Bush3

  • 1University of British Columbia , Vancouver , BC , Canada.

Fetal and Pediatric Pathology
|April 19, 2019
PubMed
Summary

Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare pediatric neck tumor. Diagnosis requires histology and immunohistochemistry, with surgical resection and long-term follow-up being crucial for management.

Keywords:
SETTLEThyroidhistologypediatric

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare neoplasm.
  • SETTLE exhibits indolent behavior with potential for late metastasis, primarily affecting children and adolescents.

Observation:

  • A case of SETTLE in an 8-year-old female is presented.
  • The patient underwent fine-needle aspiration and diagnostic biopsy.
  • No disease recurrence was observed at 3.5 years post-diagnosis.

Findings:

  • Fine-needle aspiration is valuable for initial diagnosis of SETTLE.
  • Histology, immunohistochemistry, and cytogenetics are essential for definitive diagnosis due to broad differential diagnoses.
  • Surgical resection is the primary treatment modality for SETTLE.

Implications:

  • Early diagnosis and appropriate workup are critical for managing SETTLE.
  • Long-term patient follow-up is necessary to monitor for potential recurrence or metastasis.
  • This case contributes to the limited literature on SETTLE, highlighting diagnostic and therapeutic considerations.