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Microbial Keratitis in Stevens-Johnson Syndrome: A Prospective Study

Namrata Sharma1, Renu Venugopal1, Deepali Singhal1

  • 1Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Cornea
|April 19, 2019
PubMed
Abstract

Insights

Infective keratitis is common in Stevens-Johnson syndrome (SJS), often requiring surgery. Bacterial infections, primarily Gram-positive, are frequent, but antibiotic resistance is not high, aiding treatment for SJS patients.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Dermatology

Background:

  • Stevens-Johnson syndrome (SJS) is a severe mucocutaneous reaction.
  • Infective keratitis is a serious ocular complication of SJS.

Purpose of the Study:

  • To investigate the microbiological characteristics and clinical outcomes of infective keratitis in patients with SJS.

Main Methods:

  • Retrospective analysis of 83 eyes from 68 SJS patients with microbial keratitis.
  • Standard antimicrobial therapy was administered.
  • Surgical interventions included cyanoacrylate glue and therapeutic keratoplasty.

Main Results:

  • Microbial keratitis occurred in 34% of SJS patients.
  • Bacterial infections, mainly Gram-positive, were predominant (62.5%).
  • 68.6% healed with medical therapy, but 31.3% required surgical intervention for corneal perforation.

Conclusions:

  • Infective keratitis in SJS is prevalent and frequently necessitates surgical management.
  • Antibiotic sensitivity patterns indicate manageable resistance levels.
  • Early presentation and systemic infection are risk factors for perforation.

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