Related Experiment Video
Updated: Jan 26, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings?
Emmanuel Dudoignon1,2, François Dépret1,2,3, Matthieu Legrand4,5,6
1Department of Anaesthesiology, Critical Care Medicine and Burn unit, AP-HP, Saint Louis University Hospitals, Paris, France.
Abstract:
The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of blood pressure, renal hemodynamic, myocardial contractility via an enzymatic cascade leading to the synthesis of angiotensin 2. The activation of the RAAS system after acute kidney injury triggers renal inflammation and fibrotic process with long-term damaging consequences. To date, there is still a debate on the benefits of RAAS for the kidney in acute settings. Effects of RAAS antagonists are variable in chronic or acute conditions. The aim of this review is to discuss the renal and systemic effects of the RAAS, and its modulation, in acute situations.
Related Concept Videos
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Hormonal Regulation
Acute Kidney Injury I: Introduction
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury VI: Nursing Management
Acute Kidney Injury V: Interprofessional Care

