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The double-edged sword - prosthetic joint infection following BCG treatment for bladder cancer: a case report

Minh-Vu Hoang Nguyen1, Mauro M Giordani2, George R Thompson3,4

  • 1University of California Davis Medical Center, Sacramento, CA, USA.

BMC Infectious Diseases
|April 20, 2019
PubMed
Abstract

Insights

Prosthetic joint infections can rarely stem from Bacillus Calmette-Guérin (BCG) therapy for bladder cancer. Early identification and treatment of Mycobacterium bovis joint infections are crucial for favorable outcomes.

Area of Science:

  • Infectious Diseases
  • Orthopedics
  • Oncology

Background:

  • Prosthetic joint infections (PJIs) are a significant cause of patient morbidity.
  • Unusual infectious agents require a high index of suspicion for timely diagnosis.

Observation:

  • A case of Mycobacterium bovis prosthetic joint infection is presented.
  • The infection was secondary to intravesicular Bacillus Calmette-Guérin (BCG) treatment for bladder cancer.
  • Spoligotyping definitively identified the causative agent.

Findings:

  • Surgical intervention and a 12-month anti-mycobacterial therapy led to a favorable clinical outcome.
  • Bacillus Calmette-Guérin (BCG) therapy, an M. bovis strain, is used for bladder cancer.
  • Musculoskeletal infections can occur years after BCG therapy.

Implications:

  • Awareness of BCG-related musculoskeletal infections is essential.
  • Collaboration with microbiology laboratories aids in accurate and timely identification of rare pathogens.
  • This case highlights a rare but serious complication of a common cancer therapy.
Keywords:
BCGMycobacterium bovisProsthetic joint infection

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