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Effect of stem cell transplantation on patients with ischemic heart failure: a systematic review and meta-analysis of

Yixuan Wang1, Fen Xu1, Jingwei Ma2

  • 1Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.

Stem Cell Research & Therapy
|April 20, 2019
PubMed

Insights

Stem cell transplantation (SCT) shows promise for ischemic heart failure (IHF). This meta-analysis found SCT improves heart function metrics like LVEF and reduces symptoms (NYHA class, CCS grade), without impacting mortality.

Area of Science:

  • Cardiology
  • Regenerative Medicine
  • Clinical Trials

Background:

  • Ischemic heart failure (IHF) remains a significant cause of morbidity and mortality.
  • Stem cell transplantation (SCT) has emerged as a potential therapeutic strategy for IHF.
  • Evaluating the efficacy and safety of SCT in IHF patients is crucial.

Purpose of the Study:

  • To conduct a large-scale meta-analysis of randomized clinical trials (RCTs).
  • To investigate the efficacy and safety of stem cell transplantation (SCT) for treating ischemic heart failure (IHF).
  • To synthesize evidence on SCT's impact on key clinical outcomes in IHF patients.

Main Methods:

  • Systematic search of multiple databases (PubMed, EMBASE, SpringerLink, Web of Science, Cochrane).
  • Inclusion of 14 eligible randomized controlled trials with 669 IHF patients (380 treated with SCT).
  • Meta-analysis using weighted mean difference (WMD) for clinical measures and relative risk (RR) for mortality.

Main Results:

  • SCT significantly reduced New York Heart Association (NYHA) class (MD = -0.73) and Canadian Cardiovascular Society (CCS) angina grade (MD = -0.81).
  • SCT led to a significant increase in left ventricular ejection fraction (LVEF) (MD = 6.55) and a decrease in left ventricular end-systolic volume (LVESV) (MD = -14.80).
  • No significant differences were observed in left ventricular end-diastolic volume (LVEDV) or overall mortality between SCT and control groups.

Conclusions:

  • Stem cell transplantation (SCT) demonstrates potential benefits in improving cardiac function and reducing symptoms in patients with ischemic heart failure (IHF).
  • SCT positively impacts LVEF, NYHA class, CCS grade, and LVESV.
  • Current evidence suggests SCT does not significantly alter mortality rates in IHF patients.

Keywords:
Ischemic heart failureMeta-analysisStem cell transplantation

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