Related Experiment Video
Updated: Jan 26, 2026

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
Published on: January 1, 2018
Regulation of germ cell sex identity in medaka
1Division of Biological Science, Nagoya University, Nagoya, Japan.
Abstract:
Germline stem cells are sexually indifferent or flexible even in the mature ovary and testis. Acquiring sex identity consistent with the sex of the body is a critical issue in germline stem cells for producing eggs or sperm. However, the molecular mechanism of the sexual fate decision in germ cells is unclear. Medaka is the first vertebrate in which germline stem cells were found in the mature ovary (Nakamura, Kobayashi, Nishimura, Higashijima, & Tanaka, 2010), and a germ cell autonomous switch gene involved in the sexual fate decision, foxl3, was identified (Nishimura et al., 2015) in vertebrates. Here, the mechanism underlying the sex identity of germ cells is described based on the current understanding of germ cell behavior during the sexual fate decision. The control of foxl3 expression in germ cells and components acting downstream of foxl3 are also described.
Related Concept Videos
Personal Identity
Social Identity
Sex-linked Disorders
pH Regulation in Cells
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
Marcia's Theory of Identity Status
Dissociative Identity Disorder

