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Puberty: Normal physiology (brief overview).

Claire L Wood1, Laura C Lane1, Tim Cheetham1

  • 1Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle Upon Tyne, NE1 3BZ, UK; Great North Children's Hospital, Royal Victoria Infirmary, Queen Victoria Road, Newcastle Upon Tyne, NE1 4LP, UK.

Best Practice & Research. Clinical Endocrinology & Metabolism
|April 20, 2019
PubMed
Summary
This summary is machine-generated.

Puberty marks the end of growth and the start of reproductive capability, stemming from lifelong skeletal and gonadal development. Understanding normal pubertal processes is key to identifying developmental abnormalities.

Keywords:
IGF-1anti-müllerian hormonegonadotrophingrowthgrowth hormonepuberty

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Area of Science:

  • Endocrinology
  • Human Development
  • Pediatrics

Background:

  • Puberty signifies the cessation of growth and the onset of reproductive capacity.
  • It is the culmination of continuous skeletal and gonadal activity initiated during conception.
  • While timing varies, fundamental processes of puberty are consistent across healthy individuals.

Purpose of the Study:

  • To outline the mechanisms governing normal growth and development before and during puberty.
  • To provide a foundation for understanding pathological pubertal development by defining normality.

Main Methods:

  • Review of established biological processes related to growth and sexual maturation.
  • Synthesis of information on the endocrine and physiological changes characterizing puberty.

Main Results:

  • Detailed description of the sequential events leading to and during normal puberty.
  • Identification of key biological markers and processes involved in pubertal progression.

Conclusions:

  • A comprehensive understanding of normal pubertal development is essential for diagnosing and managing deviations.
  • This framework aids in distinguishing physiological variations from pathological conditions affecting puberty.