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Updated: Jan 26, 2026
06:51
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
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Cellular Senescence in the Kidney.
Marie-Helena Docherty1, Eoin D O'Sullivan1,2, Joseph V Bonventre3
1Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK.
Journal of the American Society of Nephrology : JASN
|April 20, 2019
Summary
Senescent cells, linked to aging and kidney injury, drive organ dysfunction. Targeting these cells may extend lifespan and treat kidney disease.
Area of Science:
- Cellular senescence
- Renal pathophysiology
- Aging research
Background:
- Senescent cells exhibit permanent growth arrest and a distinct secretory phenotype.
- These cells accumulate in aging and injured kidneys, impacting organ function.
- Senescence plays roles in development, repair, and tumor suppression.
Purpose of the Study:
- To review current knowledge on senescence in the human and experimental kidney.
- To examine the dual role of senescence in kidney homeostasis and disease.
- To discuss senolytic therapies for renal conditions.
Main Methods:
- Literature review of senescence in kidney disease.
- Analysis of experimental models and human studies.
- Synthesis of evidence on senescent cell manipulation.
Main Results:
- Senescence is crucial for normal kidney development and homeostasis.
- Chronic senescent cell accumulation drives maladaptive repair, fibrosis, and transplant failure.
- Depletion of senescent cells shows promise in extending lifespan and delaying age-related diseases.
Conclusions:
- Senescence is a key factor in kidney aging and disease progression.
- Targeting senescent cells represents a promising therapeutic strategy for kidney disorders.
- Further research is needed to address uncertainties and optimize senolytic therapies for renal applications.
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