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Gender disparity in HCC: Is it the fat and not the sex?

Tim F Greten1

  • 1Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch and National Cancer Institute Center for Cancer Research Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD tim.greten@nih.gov.

The Journal of Experimental Medicine
|April 20, 2019
PubMed

Insights

Men have a higher risk of liver cancer, hepatocellular carcinoma (HCC). Researchers found that lower levels of the hormone adiponectin in males are responsible for this increased incidence.

Area of Science:

  • Hepatology
  • Endocrinology
  • Cancer Biology

Background:

  • Men exhibit a higher prevalence of hepatocellular carcinoma (HCC) compared to women.
  • The underlying biological mechanisms driving this sex disparity in HCC incidence remain largely unelucidated.

Purpose of the Study:

  • To investigate the role of adiponectin in the sex-based differences observed in hepatocellular carcinoma (HCC) development.
  • To identify potential molecular factors contributing to the higher HCC incidence in males.

Main Methods:

  • The study by Manieri et al. explored the relationship between adiponectin levels and HCC incidence in male and female subjects.
  • Analysis focused on identifying molecular pathways influenced by adiponectin that may promote HCC.

Main Results:

  • Reduced levels of the hormone adiponectin were identified as a key factor in males.
  • Lower adiponectin is linked to the increased incidence of hepatocellular carcinoma (HCC) in the male population.

Conclusions:

  • Adiponectin deficiency is a significant contributor to the elevated risk of hepatocellular carcinoma (HCC) in men.
  • Targeting adiponectin pathways may offer therapeutic strategies for mitigating HCC risk in males.

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