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Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke

C Enevold1, C H Nielsen2,3, D Molbo4

  • 1Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark. chrej@hotmail.com.

Scientific Reports
|April 20, 2019
PubMed

Insights

Blood group phenotypes were not associated with periodontitis in this Danish study. However, the Lewis (a-b-) phenotype showed a strong link to self-reported stroke, suggesting a potential hereditary predisposition.

Area of Science:

  • Genetics and Public Health
  • Cardiovascular Epidemiology
  • Oral Health Research

Background:

  • AB0 and Lewis blood groups are associated with cardiovascular diseases and obesity.
  • Periodontitis shares potential links with these conditions, suggesting common hereditary factors.
  • Investigating blood group associations with periodontitis and related disorders is crucial for understanding disease predisposition.

Purpose of the Study:

  • To examine the association between AB0 and Lewis blood group phenotypes and periodontitis in a Danish subpopulation.
  • To confirm previously reported associations between blood group phenotypes and hypertension, ischaemic heart disease, stroke, and obesity.
  • To explore potential hereditary links between blood groups and these common disorders.

Main Methods:

  • Cross-sectional study of 702 participants from a Danish cohort.
  • Analysis of AB0 and Lewis blood group phenotypes.
  • Statistical assessment of associations with periodontitis, hypertension, ischaemic heart disease, stroke, and obesity.

Main Results:

  • No significant association was found between blood group phenotype and periodontitis.
  • Previously reported associations with hypertension, ischaemic heart disease, stroke, and obesity were not confirmed.
  • A strong association was observed between the Lewis (a-b-) phenotype and self-reported stroke (OR: 22.28).

Conclusions:

  • Blood group phenotype does not appear to be a significant risk factor for periodontitis in this population.
  • The lack of confirmed associations may be due to study design and population differences.
  • The Lewis (a-b-) phenotype warrants further investigation for its potential role in stroke predisposition.

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