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Effect of fenoprofen on thyroid function tests.

J Tillman, J T Leask, J Campbell

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |December 15, 1986
    PubMed
    Summary
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    The anti-inflammatory drug fenoprofen can falsely elevate thyroid hormone levels (T3). This drug interference may lead to misdiagnosis and unnecessary treatments for patients.

    Area of Science:

    • Endocrinology
    • Clinical Chemistry
    • Pharmacology

    Background:

    • Thyroid hormone levels are critical indicators of thyroid function.
    • Non-thyroidal illnesses and medications can interfere with thyroid function tests.
    • Fenoprofen is a commonly prescribed non-steroidal anti-inflammatory drug (NSAID).

    Purpose of the Study:

    • To investigate the effect of fenoprofen on thyroid hormone levels.
    • To determine if fenoprofen causes laboratory assay interference.
    • To assess the clinical implications of fenoprofen-induced thyroid hormone alterations.

    Main Methods:

    • Observational study in patients taking fenoprofen.
    • Controlled administration of fenoprofen to volunteers.
    • Measurement of total and free triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH).

    Related Experiment Videos

  • In vitro cross-reactivity studies of fenoprofen and its metabolite (4'-hydroxyfenoprofen) with commercial T3 assay kits.

    • Main Results:

    • Fenoprofen administration led to significant increases in total T3 (doubled) and free T3 (tripled) levels in volunteers.
    • No significant changes were observed in T4 or TSH levels.
    • The metabolite 4'-hydroxyfenoprofen demonstrated cross-reactivity with Amerlex and Corning T3 assay kits, interfering with results.

    Conclusions:

    • Fenoprofen and its metabolite can interfere with specific laboratory assays for total and free T3.
    • Clinicians should be aware of this potential interference to avoid misdiagnosis of thyrotoxicosis.
    • Laboratory awareness of fenoprofen interference is crucial for accurate thyroid function testing.