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Immediate Neutrophil-Variable-T Cell Receptor Host Response in Bacterial Meningitis
Tina Fuchs1, Kerstin Puellmann2, David H Dreyfus3
1Institute for Clinical Chemistry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Frontiers in Neurology
|April 20, 2019
Summary
Neutrophils in bacterial meningitis rapidly develop novel T cell receptor (TCR)-based V(D)J immune receptors. These receptors enhance phagocytosis, indicating an immediate and flexible immune response at the infection site.
Area of Science:
- Immunology
- Neuroscience
- Infectious Diseases
Background:
- Bacterial meningitis triggers a strong neutrophil response in the central nervous system.
- Neutrophils may possess T cell receptor (TCR)-based V(D)J immune receptors, suggesting a broader role in adaptive immunity.
Purpose of the Study:
- To investigate the expression and function of neutrophil TCRαβ-based V(D)J receptors in human patients with acute bacterial meningitis.
- To understand the role of these novel receptors in the early host response to CNS bacterial infection.
Main Methods:
- Immunocytochemistry
- Genetic immunoprofiling
- Cell biology techniques
- Mass spectrometry
- Analysis of cerebrospinal fluid (CSF) and circulating neutrophils.
Main Results:
- Neutrophil V(D)J receptors are rapidly induced in CSF during early bacterial meningitis.
- Increased immune receptor repertoire diversity was observed in CSF neutrophils compared to circulating neutrophils.
- Enhanced phagocytosis of specific targets by CSF neutrophils was linked to these V(D)J receptors.
Conclusions:
- Neutrophil V(D)J receptors are part of an immediate and flexible immune response in bacterial meningitis.
- These receptors enhance neutrophil phagocytic capacity, aiding in combating CNS bacterial infections.
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