Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

System of Memory01:23

System of Memory

7.3K
Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
7.3K
Working Memory01:24

Working Memory

845
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
845
Long-Term Memory01:18

Long-Term Memory

666
Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
666
Traumatic Memory01:20

Traumatic Memory

565
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
565
Repressed Memory01:16

Repressed Memory

508
Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...
508
Immunological Memory01:23

Immunological Memory

15.2K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
15.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systems approach identifies monocyte imbalance in symptomatic and asymptomatic P. vivax malaria.

Molecular systems biology·2025
Same author

Localization modalities for botulinum neurotoxin injection.

Toxicon : official journal of the International Society on Toxinology·2025
Same author

Benchmarking spatial transcriptomics technologies with the multi-sample SpatialBenchVisium dataset.

Genome biology·2025
Same author

Dengue dynamics in Bali: Serotype shifts, genotype replacement and multiple virus lineage circulation in the last 10 years.

Tropical medicine & international health : TM & IH·2025
Same author

PD-1 blockade plus cisplatin-based chemotherapy in patients with small cell/neuroendocrine bladder and prostate cancers.

Cell reports. Medicine·2024
Same author

Role of Forkhead Box P3 in IFNγ-Mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition.

Cancer research communications·2024
Same journal

Research advances and application prospects of CAR-T therapy in the treatment of age-related diseases.

Frontiers in immunology·2026
Same journal

Machine learning-driven identification and immunohistochemical validation of an integrated immune-inflammatory phenotype for disease-free survival stratification in breast cancer.

Frontiers in immunology·2026
Same journal

Modified treatment protocol for pediatric systemic lupus erythematosus-associated hemophagocytic lymphohistiocytosis with central nervous system involvement: a case report.

Frontiers in immunology·2026
Same journal

Exploratory characterization of IgG1/IgG4 glycosylation and monocyte-derived dendritic cell responses in esophageal squamous cell carcinoma.

Frontiers in immunology·2026
Same journal

JAK-STAT pathway-associated skin diseases: a refined functional framework for inflammatory skin diseases.

Frontiers in immunology·2026
Same journal

Cross-talk among novel programmed cell death pathways: a decisive network in renal ischemia-reperfusion injury.

Frontiers in immunology·2026
See all related articles

Related Experiment Video

Updated: Jan 26, 2026

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

1.8K

Development of B Cell Memory in Malaria.

Ann Ly1,2, Diana S Hansen1,2

  • 1The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

Frontiers in Immunology
|April 20, 2019
PubMed
Summary
This summary is machine-generated.

Malaria parasite immunity is less effective than other pathogens, leading to poor B cell memory. Understanding these defects is crucial for developing new malaria therapeutics.

Keywords:
antibodiesimmunityinflammationmalariamemory B cells

More Related Videos

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
10:26

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Published on: January 16, 2015

8.8K
Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes
15:03

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

Published on: July 4, 2007

11.3K

Related Experiment Videos

Last Updated: Jan 26, 2026

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
09:13

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

1.8K
Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
10:26

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Published on: January 16, 2015

8.8K
Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes
15:03

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

Published on: July 4, 2007

11.3K

Area of Science:

  • Immunology
  • Infectious Diseases
  • Malariology

Background:

  • Unlike viral and bacterial infections that often induce lifelong immunity, immunity to Plasmodium parasites, the cause of malaria, is less efficient.
  • Naturally acquired immunity to malaria involves both cell-mediated and humoral responses, with antibodies playing a key role in controlling blood-stage infections.
  • Epidemiological data suggest that antibody generation against Plasmodium antigens is inefficient and wanes without continuous exposure, indicating impaired immunological B cell memory.

Purpose of the Study:

  • To review current findings on factors influencing memory B cell responses to malaria.
  • To identify knowledge gaps critical for designing advanced malaria therapeutics.

Main Methods:

  • Review of existing epidemiological and immunological studies on malaria infection in humans and mice.
  • Analysis of research focusing on B cell memory development in the context of Plasmodium infection.

Main Results:

  • The development of protective immunity to Plasmodium is significantly less efficient compared to other pathogens.
  • Antibodies are crucial for controlling malaria disease, but their generation and persistence are often suboptimal.
  • Evidence points to defects in the development of immunological B cell memory as a key factor in malaria's immune evasion.

Conclusions:

  • Malaria infection is characterized by inefficient B cell memory development, hindering long-term protective immunity.
  • Addressing the identified knowledge gaps in B cell memory responses is essential for the rational design of next-generation malaria vaccines and therapies.