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Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study
Jéssica-Montenegro Fonsêca1, Natália-Rangel Palmier1, Wagner-Gomes Silva2
1Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, Brasil.
Journal of Clinical and Experimental Dentistry
|April 20, 2019
Summary
Radiation directly impacts teeth, causing radiation-related caries (RRC). This study found that dentin and pulp reactions in RRC teeth are preserved, similar to conventional caries.
Area of Science:
- Oral oncology
- Dental research
- Radiation biology
Background:
- Radiation-related caries (RRC) is a significant oral toxicity following head and neck radiotherapy (HNRT).
- The direct impact of radiation on dentin and pulp, and its effect on caries progression, remains debated.
Purpose of the Study:
- To characterize the dentin-pulp complex reactions in teeth affected by radiation-related caries.
- To compare these reactions with conventional caries in head and neck cancer patients.
Main Methods:
- Histopathological analysis of 22 carious teeth from head and neck cancer patients.
- Comparison between irradiated (RRC) and non-irradiated (conventional caries) groups.
- Evaluation of pulp, blood vessels, neural elements, extracellular matrix, inflammation, and reactionary dentin using microscopy and histomorphometry.
Main Results:
- No significant difference in dentin demineralization patterns or depth between RRC and conventional caries groups.
- Mean Post-Radiation Dental Index (PRDI) scores were comparable (3.2 vs. 3.8).
- Dentin demineralization depths were similar (1,158.58µm vs. 1,056.89µm).
Conclusions:
- Pulp histopathological changes and dentin reactions are similar in both radiation-related caries and conventional caries.
- These reactions are preserved and vary with carious lesion depth and PRDI scores.
- Dentin and pulp exhibit robust preservation in radiation-related caries.
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