Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.4K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

986
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
986
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

5.0K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.0K
Impact of Individuals on Individuals01:30

Impact of Individuals on Individuals

372
Human behavior is intricately shaped by social influences that arise from interactions with others in diverse contexts. These influences not only mold beliefs and attitudes but also drive the regulation of behaviors through both direct communication and observational learning. The study of these processes falls within the domain of social psychology, which seeks to understand how individuals are affected by and affect those around them.Mechanisms of Social InfluenceDirect social influence...
372
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.3K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.3K
Impact of Groups on Individuals01:28

Impact of Groups on Individuals

331
Groups play a fundamental role in shaping individual behavior, as they establish norms that guide interactions and decision-making. Social psychology examines how individuals conform to group expectations, often adjusting their attitudes and actions to align with group norms. These norms can be formal, such as workplace policies, or informal, such as unspoken social expectations within a fraternity.Conformity and Social InfluenceConformity arises when individuals modify their behaviors or...
331

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Deciphering cardiovascular cell heterogeneity with single cell RNA sequencing.

Frontiers in medicine·2026
Same author

Impact of aging on CD146<sup>+</sup> mesenchymal stromal cells-mediated regulation of bone marrow CD34<sup>+</sup> hematopoietic stem/progenitor cell mobilization.

Frontiers in bioengineering and biotechnology·2026
Same author

Decoding human longevity: Genetic and molecular insights from accelerated to successful ageing.

Ageing research reviews·2026
Same author

WITHDRAWN: Corrigendum to "NADPH oxidase 5 promotes adhesion and infiltration of immune cells in the brain. Implications in ischemic stroke" [Biochim. Biophys. Acta (BBA) - Mol. Basis Dis. (2026) volume 1872, issue 4, 168188].

Biochimica et biophysica acta. Molecular basis of disease·2026
Same author

Endothelial triple-pathway vasorelaxation as an adjunctive strategy in resistant hypertension.

Journal of hypertension·2026
Same author

Senescence-related myocardial dysfunction: keeping a young heart.

European heart journal·2026

Related Experiment Video

Updated: Jan 26, 2026

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
10:07

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

9.5K

Bone marrow pericyte dysfunction in individuals with type 2 diabetes.

Giuseppe Mangialardi1, David Ferland-McCollough1, Davide Maselli1,2,3

  • 1Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Level 7, Upper Maudlin Street, Bristol, BS2 8HW, UK.

Diabetologia
|April 20, 2019
PubMed
Summary
This summary is machine-generated.

Type 2 diabetes impairs bone marrow pericyte function, reducing their ability to support blood vessel formation. This dysfunction, linked to altered signaling, may contribute to microvascular changes in diabetic bone marrow.

Keywords:
Angiocrine factorsBone marrowDiabetesMicroangiopathyPericytes

More Related Videos

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

983
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Related Experiment Videos

Last Updated: Jan 26, 2026

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
10:07

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

9.5K
Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

983
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Area of Science:

  • Endocrinology
  • Vascular Biology
  • Hematology

Background:

  • Diabetes mellitus is known to destabilize microvasculature integrity in various organs.
  • Bone marrow pericytes play crucial roles in supporting endothelial and hematopoietic cells via paracrine mechanisms.
  • The impact of diabetes on bone marrow pericyte function remained largely unexplored.

Purpose of the Study:

  • To investigate the effects of type 2 diabetes on the abundance and function of bone marrow pericytes.
  • To determine if bone marrow pericytes are a direct target of diabetes-induced damage.

Main Methods:

  • An observational clinical study compared CD146+ pericytes from bone marrow of individuals with and without type 2 diabetes.
  • Abundance, molecular, and functional characteristics of pericytes were analyzed using immunohistochemistry, flow cytometry, and in vitro assays.
  • Signaling pathways, including AKT phosphorylation and angiocrine factors (FGF2, CXCL12, ANGPT2), were assessed.

Main Results:

  • Type 2 diabetes did not alter CD146+ pericyte counts but caused capillary rarefaction and arteriole compression in bone marrow.
  • Diabetic pericytes exhibited reduced proliferation, viability, migration, and in vitro angiogenesis support, alongside increased apoptosis.
  • While AKT phosphorylation was unchanged, angiocrine signaling was downregulated (decreased FGF2/CXCL12, increased ANGPT2); AKT activation rescued these defects.

Conclusions:

  • This study provides the first evidence of pericyte dysfunction in the bone marrow of individuals with type 2 diabetes.
  • Altered angiocrine signaling from bone marrow pericytes may contribute to microvascular remodeling in diabetes.
  • Targeting pericyte dysfunction and signaling represents a potential therapeutic avenue for diabetic complications.