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[Continuation of ICD treatment at the time of device exchange without adequate treatment?]
Konstantin Krieger1, Corinna Lenz2
1Klinik für Innere Medizin und Kardiologie, Unfallkrankenhaus Berlin, Warenerstraße 7, 12683, Berlin, Deutschland. Konstantin.Krieger@ukb.de.
Insights
Elective implantable cardioverter-defibrillator (ICD) replacement offers a chance to reassess treatment for patients with heart failure. Discontinuing ICD therapy may be an option for select patients, considering factors like ejection fraction and comorbidities.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Device Technology
Background:
- Increasingly older heart failure patients with comorbidities undergo elective device exchange.
- This demographic shift necessitates re-evaluating implantable cardioverter-defibrillator (ICD) treatment protocols.
- Higher complication rates in this population highlight the need for individualized care.
Purpose of the Study:
- To review literature on continuing ICD therapy versus device exchange in patients without adequate ICD treatment.
- To explore criteria for discontinuing or modifying ICD therapy during elective replacement.
Main Methods:
- Literature review focusing on patients with prophylactic ICD indications and no adequate treatment.
- Analysis of factors influencing ventricular arrhythmia (VA) risk, including left ventricular ejection fraction (LVEF).
- Consideration of patient demographics (age, sex) and comorbidities.
Main Results:
- Patients with improved LVEF (>35%) and prophylactic ICD indications have a lower VA risk post-exchange.
- Individualized discussion is crucial for continuing ICD treatment in older patients with comorbidities.
- Discontinuation or downgrading to CRT-P may be suitable for female patients with non-ischemic cardiomyopathy and normalized LVEF, especially with CRT.
Conclusions:
- Discontinuation of ICD therapy can be considered during elective exchange for prophylactic indications in untreated patients.
- Individualized decisions require assessment of LVEF, age, sex, and comorbidities.
- Lack of prospective randomized studies prevents general recommendations.
Introduction:
Due to improved treatment of heart failure, patients are older and have more comorbidities at the time of an elective device exchange. This leads to higher rates of complications and represents an opportunity for re-evaluation of the implantable cardioverter defibrillator (ICD) treatment.
Objective:
This article reviews the current literature regarding the indications for continued ICD therapy and device exchange in patients who have never received adequate treatment through the ICD.
Material And Methods:
Patients with primarily prophylactic indications, who have not received adequate treatment and have shown significant improvement in the left ventricular ejection fraction (LVEF) >35%, have a significantly lower risk of ventricular arrythmia (VA) after device exchange. Although further ventricular events can occur in these patients, the continuation of ICD treatment should be individually discussed in cases of high age and increased comorbidities. In female patients with a non-ischemic cardiac myopathy and an almost normalized LVEF, mostly during cardiac resynchronization therapy (CRT), a discontinuation of ICD treatment or downgrading to CRT with pacemaker (CRT-P) treatment should be discussed.
Conclusion:
At the time of an elective device exchange for primarily prophylactic indications, the possibility to discontinue ICD treatment can be discussed with patients who have not experienced adequate treatment. Additional factors, such as LVEF, age, sex and comorbidities of the patient should be taken into consideration in order to make an individualized decision. As prospective randomized studies are lacking, it is not possible to give generally valid recommendations.
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