Related Experiment Video
Updated: Jan 26, 2026
09:36
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
26.2K
[Long non-coding RNA and cervical cancer]
Wenhui Fu1, Gan Hou1, Dinan Huang1
1Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang 524023, Guangdong, China.
Summary
Long non-coding RNAs (lncRNAs), once dismissed as noise, are now recognized as crucial regulators in biological processes, including cervical cancer development. Research highlights their abnormal expression and regulatory roles in this disease.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are RNA molecules similar to messenger RNA (mRNA) but lack protein-coding potential.
- Initially considered transcriptional byproducts, lncRNAs are now understood as key regulators in various biological processes.
- Aberrant lncRNA expression is implicated in diseases, including nervous system disorders, metabolic diseases, and cancer.
Purpose of the Study:
- To review recent findings on the abnormal regulation of lncRNAs in cervical cancer.
- To elucidate the molecular mechanisms by which lncRNAs regulate cervical cancer.
- To explore the potential clinical applications of lncRNAs in cervical cancer diagnosis and treatment.
Main Methods:
- Literature review of recent scientific reports and studies.
- Analysis of lncRNA expression patterns in cervical cancer.
- Investigation of molecular pathways influenced by lncRNAs in cervical cancer progression.
Main Results:
- lncRNAs are frequently abnormally expressed in cervical cancer tissues.
- These dysregulated lncRNAs can act as either tumor suppressors or oncogenes.
- lncRNAs influence critical cellular processes in cervical cancer, such as proliferation, migration, and apoptosis.
Conclusions:
- lncRNAs play significant roles in the development and progression of cervical cancer.
- Understanding lncRNA regulation mechanisms offers insights into cervical cancer pathogenesis.
- lncRNAs hold promise as biomarkers and therapeutic targets for cervical cancer.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
02:39lncRNA - Long Non-coding RNAs
3.6K
3.6K
01:32RNA Splicing
60.5K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.5K
02:53Ribosomal RNA Synthesis
14.7K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.7K
01:29Nursing Code of Ethics
4.3K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.3K
02:36Transfer RNA Synthesis
13.3K
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
13.3K