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CD18 inhibits progression of kidney cancer by down-regulating Treg cell levels

J-H Fu1, C-C Zhou, H-Q Mu

  • 1Department of Urology, Dongyang People's Hospital, Dongyang, Zhejiang, China. bdyt0zxc526s@sina.com.

European Review for Medical and Pharmacological Sciences
|April 20, 2019
PubMed
Abstract

Insights

CD18 deficiency significantly reduces regulatory T cells (Treg) and inhibits renal cell carcinoma progression in mice. This finding suggests CD18 plays a role in kidney cancer development.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Gene mutations are linked to tumor development.
  • Renal cell carcinoma (RCC) is a serious cancer.
  • Regulatory T cells (Treg) influence cancer progression.

Purpose of the Study:

  • To investigate the effect of CD18 on renal cell carcinoma proliferation.
  • To explore the role of CD18 in kidney cancer pathogenesis.

Main Methods:

  • Utilized CD18-deficient and C57 mice models for renal cell carcinoma.
  • Assessed Ki67 proliferation marker and micro-vessel density via IHC and immunofluorescence.
  • Quantified CD3, CD4, CD8 expression using q-PCR and Treg cell populations via flow cytometry.

Main Results:

  • CD18 deficiency led to significantly lower Ki67 expression and CD31 levels.
  • Reduced Treg cell populations were observed in CD18-deficient mice.
  • High CD4 expression in lymph nodes indicated a non-tumor-bearing state in CD18-/- mice.

Conclusions:

  • CD18 deficiency down-regulates Treg cells.
  • CD18 deficiency inhibits the pathogenesis of renal cell carcinoma.
  • CD18 is a potential target for kidney cancer therapy.

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