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HOXD-AS1: a novel oncogenic long intergenic non-coding RNA in humans.

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Long non-coding RNAs like HOXD-AS1 are implicated in cancer. This review details HOXD-AS1

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Long non-coding RNAs (lncRNAs) are critical regulators of biological processes.
  • Dysregulation of lncRNAs is observed in human diseases, particularly cancers.
  • The specific roles of many lncRNAs, including HOXD-AS1, in oncogenesis are not fully understood.

Purpose of the Study:

  • To review recent advances in the function, role, regulation, and oncogenic properties of HOXD-AS1.
  • To consolidate current knowledge on HOXD-AS1's involvement in various cancers.

Main Methods:

  • A systematic literature review was performed using PubMed.
  • Searched for articles on HOXD-AS1 and cancer published up to June 2018.
  • Focused on studies detailing the molecular mechanisms and clinical relevance of HOXD-AS1.

Main Results:

  • HOXD-AS1 is overexpressed in numerous cancers and functions as an oncogene.
  • It influences key cellular processes: proliferation, apoptosis, migration, invasion, metastasis, and chemoresistance.
  • HOXD-AS1 interacts with proteins and sequesters microRNAs (e.g., miR-608, miR-130a, miR-217) to modulate gene expression.

Conclusions:

  • HOXD-AS1 plays a significant role in cancer development and progression.
  • HOXD-AS1 holds potential as a prognostic biomarker for cancer.
  • HOXD-AS1 represents a promising therapeutic target for cancer treatment.