Related Experiment Video
Updated: Jan 26, 2026

Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels
Published on: July 3, 2025
Endotipsitis as an indication for pediatric liver transplantation
Javier Juamperez1, Jesús Quintero1, Antoni Muntaner1
1Pediatric Liver Transplantation Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
Insights
Endotipsitis, a rare complication of transjugular intrahepatic portosystemic shunt (TIPS), was identified in a pediatric patient with biliary atresia. This case highlights the potential for device infection in children undergoing TIPS for portal hypertension.
Area of Science:
- Pediatric Gastroenterology
- Interventional Radiology
- Infectious Diseases
Background:
- Transjugular intrahepatic portosystemic shunt (TIPS) is used for portal hypertension but rarely in children.
- Biliary atresia is a condition requiring surgical intervention and potentially leading to complications like portal hypertension.
- Endotipsitis is a severe but infrequent complication associated with TIPS placement.
Abstract:
Endotipsitis is a rare but severe complication of transjugular intrahepatic portosystemic shunt (TIPS), a device widely used to treat portal hypertension in adults, but sparsely used in children. We report a case of endotipsitis in a 3-year-old child affected of biliary atresia. She underwent a Kasai procedure at 3 months of age but, although the bile flow was restored, she presented upper gastrointestinal bleeding due to portal hypertension 1.5 years later. A TIPS was placed in order to control the hemorrhage. A year after TIPS placement, she started presenting repeated episodes of cholangitis. Blood cultures were positive to Enterobacter cloacae. Even with long antibiotic courses, adjusted to blood cultures, infectious signs were observed after antibiotic withdrawal. Device infection was demonstrated through Positron emission tomography-Computed tomography scan. The patient was listed for liver transplantation, and intravenous antibiotic treatment was maintained until stent removal during the liver transplant 8 months later. No infectious complications were demonstrated after the surgery. To the best of our knowledge, this is the first case report of endotipsitis described in a pediatric patient.
Related Concept Videos
Indicators
Mechanical Ventilation I: Indication and Settings
Respiratory Assessment: Purpose and Indications
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Drug Metabolism

