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Circulating PCSK9 concentrations are increased in postmenopausal women with the metabolic syndrome
1School of Allied Health Sciences, Walailak University, 222 Thaiburi, Thasala, Nakhon Si Thammarat, Thailand.
Insights
Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are higher in Thai women, especially postmenopausal women with metabolic syndrome (MetS). Elevated PCSK9 is linked to increased cardiovascular disease risk in this group.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Metabolic Health
Background:
- High proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations are linked to increased cardiovascular disease (CVD) risk.
- PCSK9 plays a crucial role in cholesterol metabolism and CVD pathogenesis.
Purpose of the Study:
- To investigate PCSK9 concentrations and their association with metabolic parameters in Thai subjects.
- To compare PCSK9 levels in pre- and postmenopausal women with and without metabolic syndrome (MetS).
Main Methods:
- Measured anthropometric data, serum lipids, fasting blood glucose (FBG), and PCSK9 concentrations in 436 Thai subjects.
- Included 152 men, 143 premenopausal women, and 141 postmenopausal women.
Main Results:
- PCSK9 concentrations were significantly higher in women than men and increased with more MetS components.
- Postmenopausal women had higher PCSK9 than premenopausal women, and those with MetS had higher levels than those without.
- PCSK9 positively correlated with age, BMI, SBP, total cholesterol, triglyceride, LDL-C, and FBG.
Conclusions:
- PCSK9 concentrations are influenced by age, gender, MetS, and menopausal status in Thai individuals.
- Elevated PCSK9 may heighten cardiovascular risk, particularly in postmenopausal women with MetS.
Background:
High PCSK9 concentrations are associated with an increased risk of cardiovascular disease (CVD). We investigated PCSK9 concentrations and their association with metabolic parameters in Thai subjects and to compare PCSK9 concentrations in pre- and postmenopausal women with and without metabolic syndrome (MetS).
Methods:
Anthropometric data, serum lipids, fasting blood glucose (FBG), and PCSK9 concentrations were measured in 436 Thai subjects (152 men, 143 premenopausal, and 141 postmenopausal women).
Results:
PCSK9 concentrations were significantly higher in women than in men (p = .002) and increased in subjects with an increasing number of MetS components (p for trend = .011). PCSK9 concentrations were significantly higher in postmenopausal women than in premenopausal women (p < .001), in the MetS group than in the non-MetS group (p = .037), and in postmenopausal women with MetS than in premenopausal women without MetS (p < .001). Serum PCSK9 concentrations were positively correlated with several metabolic parameters, including age, BMI, systolic blood pressure (SBP), total cholesterol, triglyceride, LDL-C, and FBG.
Conclusion:
PCSK9 concentrations are influenced by age, gender, MetS status, and menopausal status among Thai subjects. These findings suggest that an elevation in PCSK9 concentrations may increase cardiovascular risk in postmenopausal women with MetS.
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