Related Experiment Video
Updated: Jan 26, 2026
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
7.6K
The Endocannabinoid/Endovanilloid System in Bone: From Osteoporosis to Osteosarcoma
Francesca Rossi1, Chiara Tortora2, Francesca Punzo3,4
1Department of Women, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, 80138 Naples, Italy. francesca.rossi@unicampania.it.
International Journal of Molecular Sciences
|April 21, 2019
Summary
The endocannabinoid/endovanilloid (EC/EV) system influences bone health by modulating osteoclast and osteoblast activity. Targeting EC/EV receptors offers a promising therapeutic strategy for bone diseases like osteoporosis and bone cancer.
Area of Science:
- Bone Biology
- Pharmacology
- Endocrinology
Background:
- Bone homeostasis relies on a balance between osteoclast and osteoblast activity.
- The endocannabinoid/endovanilloid (EC/EV) system, including CB1, CB2, and TRPV1 receptors, modulates bone remodeling.
- Bone diseases like osteoporosis are prevalent globally, stemming from factors including estrogen decline, glucocorticoids, and chemotherapy.
Purpose of the Study:
- To investigate the role of the EC/EV system in bone homeostasis and disease.
- To explore the potential of EC/EV receptors as therapeutic targets for bone disorders.
- To review the dual effects of EC/EV receptor stimulation on bone formation and resorption.
Main Methods:
- Review of existing literature on EC/EV system components (CB1, CB2, TRPV1) and their impact on bone cells.
- Analysis of studies investigating EC/EV system modulation in osteoporosis and bone cancer models.
- Exploration of the therapeutic potential of targeting EC/EV receptors.
Main Results:
- CB1 and TRPV1 receptor stimulation promotes osteoclast activity (bone resorption).
- CB2 receptor stimulation exhibits an anti-osteoclastogenic effect (inhibits bone resorption).
- EC/EV system modulation in bone cancer reduces tumor growth, invasion, and pain in mouse models.
Conclusions:
- EC/EV receptors are critical regulators of bone remodeling and hold therapeutic potential for bone diseases.
- Targeting EC/EV receptors could offer a novel approach for managing osteoporosis and bone cancer.
- Further research into the biochemical mechanisms of the EC/EV system in bone is warranted, with hybrid molecules showing promise.
More Related Videos
06:59Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
3.5K
04:25Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
11.3K
Related Concept Videos
01:09Spongy Bone
7.7K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
7.7K
01:27Compact Bone
16.3K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.3K
01:29Bone Disorders
5.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.1K
01:12The Hyoid Bone
4.9K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
4.9K
01:55Bone Structure
51.6K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.6K
01:40Bone Remodeling
40.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.3K