Short Cationic Peptidomimetic Antimicrobials
Rajesh Kuppusamy1, Mark Willcox2, David StC Black3
1School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia. r.kuppusamy@ad.unsw.edu.au.
Abstract:
The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to their rapid killing and broad-spectrum activity. Peptidomimetics overcome some of the obstacles of AMPs such as high cost of synthesis, short half-life in vivo due to their susceptibility to proteolytic degradation, and issues with toxicity. This review will examine the development of short cationic peptidomimetics as antimicrobials.
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