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Updated: Jan 26, 2026
11:48
Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
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Long Noncoding RNA and Epithelial Mesenchymal Transition in Cancer
Mila Gugnoni1, Alessia Ciarrocchi2
1Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy. mila.gugnoni@ausl.re.it.
International Journal of Molecular Sciences
|April 21, 2019
Summary
Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in regulating epithelial-mesenchymal transition (EMT). This review explores how lncRNAs influence EMT and their potential as cancer biomarkers and therapeutic targets.
Area of Science:
- Molecular Biology
- Cancer Biology
- Genomics
Background:
- Epithelial-mesenchymal transition (EMT) is crucial for embryonic development and is aberrantly activated in cancer, promoting metastasis.
- Noncoding DNA, particularly long noncoding RNAs (lncRNAs), plays a significant regulatory role in gene expression.
- Over 8000 lncRNAs are selectively expressed in cancer cells, suggesting potential as biomarkers and therapeutic targets.
Purpose of the Study:
- To summarize current findings on the role of lncRNAs in regulating EMT.
- To discuss the potential of lncRNAs as biomarkers and therapeutic targets in cancer.
Main Methods:
- Literature review of genomic sequencing and functional genomic studies.
- Analysis of existing research on lncRNA expression and function in cancer.
- Synthesis of evidence linking lncRNAs to EMT regulation.
Main Results:
- lncRNAs regulate gene expression at multiple levels, influencing cellular processes.
- Evidence highlights a significant function of lncRNAs in EMT regulation.
- lncRNAs are increasingly implicated in cancer biology through their role in EMT.
Conclusions:
- lncRNAs represent a novel layer of regulation in cancer biology via EMT.
- lncRNAs hold promise as valuable biomarkers for cancer detection and prognosis.
- Targeting lncRNAs offers a potential new therapeutic strategy for cancer treatment.
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