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Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Body composition changes in diabetes and aging.

Mohammed E Al-Sofiani¹, Suneeta S Ganji², Rita R Kalyani²

¹Division of Endocrinology, Diabetes & Metabolism, The Johns Hopkins University, Baltimore, MD, United States of America; Division of Endocrinology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Journal of Diabetes and Its Complications

|April 21, 2019

Summary

This summary is machine-generated.

Aging leads to body composition changes, increasing type 2 diabetes risk. This review examines how diabetes impacts these changes and treatment effects on body composition.

Keywords:

Aging Body composition Diabetes Fat mass Lean mass Muscle mass

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Area of Science:

Gerontology and Endocrinology
Metabolic Health and Body Composition

Background:

Aging is linked to detrimental body composition shifts, including increased adiposity and decreased muscle mass, elevating type 2 diabetes mellitus (T2DM) risk.
Altered fat distribution during aging may further exacerbate T2DM development.
Emerging evidence suggests age-related body composition changes may be both a risk factor for and a consequence of T2DM.

Purpose of the Study:

To review and synthesize current evidence on body composition alterations in adults following a type 2 diabetes diagnosis.
To compare age-related body composition changes in individuals with and without diabetes.
To examine the impact of glucose-lowering interventions (lifestyle, pharmacological, surgical) on body composition in adults with T2DM.

Main Methods:

Systematic literature review and evidence synthesis.
Comparative analysis of body composition data based on diabetes status and age.
Evaluation of intervention effects on body composition parameters.

Main Results:

Significant differences exist in age-related body composition changes between individuals with and without type 2 diabetes.
Body composition changes can be both a precursor and a result of type 2 diabetes.
Various treatments targeting blood glucose levels demonstrate varying effects on body composition in diabetic adults.

Conclusions:

Body composition changes are intricately linked with aging and type 2 diabetes, influencing disease risk and progression.
Understanding these bidirectional relationships is crucial for effective diabetes management.
Interventions aimed at improving glycemic control can modulate body composition, warranting further investigation into optimal therapeutic strategies.