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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Electrical Current01:10

Electrical Current

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Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
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Extraction: Advanced Methods00:56

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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

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Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
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Updated: Jan 26, 2026

Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm
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Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm

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Current advances in haploid stem cells.

Tongtong Cui1,2,3, Zhikun Li1,2,3, Qi Zhou1,2,3

  • 1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

Protein & Cell
|April 21, 2019
PubMed
Summary
This summary is machine-generated.

Haploid stem cells, derived in vitro, offer unique developmental potential for mammals. These artificial cells are revolutionizing genetic screens and assisted reproduction, unlocking new biological insights.

Keywords:
androgeneticdiploidizationfunctional genomicshaploidyimprintingparthenogeneticstem cells

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Area of Science:

  • Genomics
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Mammals typically exhibit diploidy, possessing two sets of chromosomes.
  • Haploid stem cells are artificial cell lines created in vitro.
  • These cells combine haploid genetic status with significant developmental potential.

Purpose of the Study:

  • To review the generation of haploid stem cells.
  • To discuss the unique properties of these cells.
  • To highlight their broad applications in biological research and reproduction.

Main Methods:

  • Experimental derivation of haploid stem cell lines in vitro.
  • Characterization of cell properties and developmental potential.
  • Application in high-throughput genetic screens and assisted reproduction.

Main Results:

  • Successful derivation of various haploid stem cell types from multiple mammalian species (mouse, rat, monkey, human).
  • Demonstrated utility in high-throughput genetic screening.
  • Potential applications in mammalian assisted reproduction.

Conclusions:

  • Haploid stem cells represent a significant advancement in stem cell research.
  • Their unique properties facilitate the study of biological processes at a genomic scale.
  • These cells hold promise for future applications in genetics and reproductive technologies.