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Updated: Jan 26, 2026
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Precise Cellular Ablation Approach for Modeling Acute Kidney Injury in Developing Zebrafish
Published on: June 3, 2017
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Drugs in Development for Acute Kidney Injury
Matthew Hulse1, Mitchell H Rosner2
1Divison of Critical Care, Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA, 22908, USA.
Drugs
|April 21, 2019
Summary
Effective treatments for acute kidney injury (AKI) are lacking. New research into AKI
Area of Science:
- Nephrology
- Translational Medicine
- Pharmacology
Background:
- Current management of acute kidney injury (AKI) lacks effective preventative or therapeutic options.
- Significant advancements in understanding AKI pathogenesis have revealed numerous potential therapeutic targets.
Purpose of the Study:
- To review the current landscape of therapeutic targets for acute kidney injury (AKI).
- To highlight novel approaches in AKI treatment and patient stratification.
Main Methods:
- Review of scientific literature on AKI pathogenesis and therapeutic targets.
- Analysis of pathways implicated in AKI, including inflammation, fibrosis, metabolism, oxidative stress, apoptosis, and hemodynamics.
- Discussion of early-phase clinical trial compounds and endo-phenotyping strategies.
Main Results:
- Identification of multiple molecular pathways as potential targets for AKI therapeutics.
- Progress in developing novel compounds targeting these pathways, with many in early clinical trials.
- Endo-phenotyping offers a promising approach for personalized AKI therapy.
Conclusions:
- Advances in understanding AKI pathogenesis are paving the way for new treatments.
- Targeted therapies and personalized approaches hold promise for transforming AKI patient care and outcomes.
- Optimism exists for improved clinical outcomes in AKI patients due to ongoing research and development.
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