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Drugs in Development for Acute Kidney Injury

Matthew Hulse1, Mitchell H Rosner2

  • 1Divison of Critical Care, Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA, 22908, USA.

Drugs
|April 21, 2019
PubMed

Insights

Effective treatments for acute kidney injury (AKI) are lacking. New research into AKI

Area of Science:

  • Nephrology
  • Translational Medicine
  • Pharmacology

Background:

  • Current management of acute kidney injury (AKI) lacks effective preventative or therapeutic options.
  • Significant advancements in understanding AKI pathogenesis have revealed numerous potential therapeutic targets.

Purpose of the Study:

  • To review the current landscape of therapeutic targets for acute kidney injury (AKI).
  • To highlight novel approaches in AKI treatment and patient stratification.

Main Methods:

  • Review of scientific literature on AKI pathogenesis and therapeutic targets.
  • Analysis of pathways implicated in AKI, including inflammation, fibrosis, metabolism, oxidative stress, apoptosis, and hemodynamics.
  • Discussion of early-phase clinical trial compounds and endo-phenotyping strategies.

Main Results:

  • Identification of multiple molecular pathways as potential targets for AKI therapeutics.
  • Progress in developing novel compounds targeting these pathways, with many in early clinical trials.
  • Endo-phenotyping offers a promising approach for personalized AKI therapy.

Conclusions:

  • Advances in understanding AKI pathogenesis are paving the way for new treatments.
  • Targeted therapies and personalized approaches hold promise for transforming AKI patient care and outcomes.
  • Optimism exists for improved clinical outcomes in AKI patients due to ongoing research and development.

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