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Neural substrates of self- and external-preoccupation: A voxel-based morphometry study.
Shigeyuki Ikeda1, Hikaru Takeuchi2, Yasuyuki Taki2,3,4
1Department of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Brain and Behavior
|April 21, 2019
Summary
This study reveals distinct brain structures linked to self-preoccupation and external-preoccupation. Understanding these neural substrates may offer insights into psychopathological states.
Area of Science:
- Neuroimaging
- Cognitive Neuroscience
- Psychiatry
Background:
- Self- and external-preoccupation are associated with psychopathological conditions.
- The specific brain mechanisms underlying these preoccupations are not fully understood.
- Investigating structural differences can illuminate information-processing in these states.
Purpose of the Study:
- To identify the distinct neural substrates of self- and external-preoccupation.
- To explore the relationship between regional gray matter volume and preoccupation tendencies.
- To provide structural insights into the information processing of self- and external-focus.
Main Methods:
- Acquired high-resolution T1-weighted structural MRI scans from 1,122 young individuals.
- Administered the Preoccupation Scale to assess self- and external-preoccupation.
- Utilized voxel-based morphometry to analyze associations between regional gray matter volume and preoccupation scores.
Main Results:
- Positive associations between self-preoccupation and regional gray matter volume (rGMV) were found in the bilateral precuneus and posterior cingulate gyri.
- These areas are implicated in self-referential thought and resting-state processing.
- Negative associations between external-preoccupation and rGMV were identified in the bilateral cerebellum, linked to attention and reward systems.
Conclusions:
- Distinct structural neural substrates differentiate self- and external-preoccupation.
- These findings contribute to understanding the neurobiology of preoccupation and its potential role in psychopathology.
Keywords:
Preoccupation Scalecerebellumgray matter volumemagnetic resonance imagingposterior cingulate cortexprecuneusMore Related Videos
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