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Related Experiment Videos

[Experiences with L-carnitine in the post-stress phase].

D Balogh, J M Hackl, E Legenstein

    Infusionstherapie Und Klinische Ernahrung
    |October 1, 1986
    PubMed
    Summary

    Carnitine supplementation in multiple injured patients enhanced fatty acid oxidation, indicated by lower free fatty acids and higher alpha-hydroxy-butyrate. However, it did not reduce overall catabolism or improve carbohydrate metabolism.

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    Area of Science:

    • Biochemistry
    • Metabolic Research
    • Clinical Nutrition

    Background:

    • Multiple injured patients often experience metabolic disturbances.
    • Carnitine plays a crucial role in fatty acid metabolism.
    • Investigating carnitine's impact on metabolism in trauma is essential.

    Purpose of the Study:

    • To evaluate the effect of carnitine supplementation on metabolic parameters in multiple injured patients.
    • To assess carnitine's influence on fatty acid, carbohydrate, and amino acid metabolism.

    Main Methods:

    • Prospective, randomized, double-blind study in 24 multiple injured patients.
    • Combined parenteral-enteral nutrition for 7 days.
    • Carnitine (60 mg/kg BW) administered via continuous infusion to the treatment group; various metabolic markers analyzed.

    Main Results:

    • Increased plasma acetyl-carnitine and urinary acetyl-carnitine excretion in the carnitine group.
    • Markedly lower plasma free fatty acids (FFA) and elevated alpha-hydroxy-butyrate, indicating increased fatty acid oxidation.
    • No significant differences in carbohydrate metabolism; slight increase in urea production and augmented urinary alpha-aminonitrogen excretion.

    Conclusions:

    • Carnitine supplementation enhances fatty acid oxidation in multiple injured patients.
    • Carnitine administration does not improve carbohydrate metabolism or reduce overall catabolism.
    • Increased urinary excretion of alpha-aminonitrogen may be due to carnitine's amino acid nature or renal tubular effects.

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