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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Purification of Ubiquitinated p53 Proteins from Mammalian Cells

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Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

Haroon Khan1, Marcella Reale2, Hammad Ullah3

  • 1Department of Pharmacy, Abdul Wali Khan University, Pakistan..

Biotechnology Advances
|April 21, 2019
PubMed

Insights

Dietary polyphenols can activate the tumor suppressor gene p53, crucial for cancer prevention. This review explores how these compounds upregulate p53 expression for chemopreventive effects.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • The tumor suppressor gene tumor protein 53 (p53) plays a critical role in preventing cancer.
  • p53 expression is often suppressed in various cancer types.
  • Polyphenols are bioactive compounds found in numerous dietary sources with potential health benefits.

Purpose of the Study:

  • To review the significance of p53 signaling pathways in cancer.
  • To elucidate the molecular mechanisms by which dietary polyphenols influence p53 expression.
  • To highlight the role of p53 upregulation by polyphenols in cancer chemoprevention.

Main Methods:

  • Literature review of studies investigating polyphenol-p53 interactions.
  • Analysis of molecular mechanisms underlying p53 modulation by polyphenols.
  • Focus on studies examining p53 expression in cancer cell lines treated with dietary polyphenols.

Main Results:

  • Dietary polyphenols can upregulate the expression of the tumor suppressor gene p53.
  • Distinct mechanisms of action are involved in polyphenol-mediated p53 activation.
  • Restoring p53 expression is a key factor in the anticancer effects of polyphenols.

Conclusions:

  • Dietary polyphenols hold significant potential for cancer chemoprevention.
  • Targeting p53 signaling pathways with polyphenols is a promising therapeutic strategy.
  • Further research into polyphenol-p53 interactions can lead to novel cancer treatments.
Keywords:
AnticancerChemoresistanceClinical perspectivesPolyphenolsp53 signaling pathways

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