Related Experiment Video

Updated: Jan 26, 2026

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
07:08

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

8.9K

In vitro assessment of edoxaban anticoagulant effect in pediatric plasma

Thomas Sinegre1, Mélissa Zlobecki2, Eric Doré3

  • 1CHU Clermont-Ferrand, Service d'Hématologie Biologique, Clermont-Ferrand, France; Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France.

Thrombosis Research
|April 22, 2019
PubMed

Insights

Direct oral anticoagulants like edoxaban show promise for children. In vitro studies found edoxaban

Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Hematology

Background:

  • Anticoagulant therapy in children presents challenges.
  • Direct oral anticoagulants (DOACs) offer potential safer alternatives.
  • Edoxaban, a factor Xa inhibitor, is a candidate for pediatric use.

Purpose of the Study:

  • To compare the in vitro anticoagulant effects of edoxaban in pediatric and adult populations.
  • To evaluate edoxaban's dose-dependent activity across different age groups.

Main Methods:

  • Prospective collection of blood samples from 87 adults and 97 children across various age strata.
  • In vitro addition of edoxaban to plasma samples at concentrations of 50, 150, and 300 ng/mL.
  • Assessment of edoxaban's impact on prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, anti-factor Xa activity, and thrombin generation assay (TGA).

Main Results:

  • Edoxaban demonstrated dose-dependent effects on PT, aPTT, and anti-factor Xa activity, consistent across adult and pediatric groups.
  • Thrombin peak reduction in TGA was similar between adults and children.
  • A significantly higher reduction in thrombin peak was observed in the youngest pediatric group (<2 years old) compared to adults at all tested edoxaban concentrations.

Conclusions:

  • Edoxaban exhibits comparable in vitro anticoagulant effects in children and adults.
  • The <2-year-old pediatric group showed a more pronounced response to edoxaban's anticoagulant effect.
  • These findings support edoxaban's potential as a safer anticoagulant option for pediatric patients, with potential age-specific considerations for the youngest.
Abstract

Keywords:
CoagulationEdoxabanPediatricThrombin generation

More Related Videos

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions07:39

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Published on: November 17, 2021

3.9K
Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion08:34

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

Published on: February 24, 2021

3.0K

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.2K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.8K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
276
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
200
Composition of Blood Plasma01:24

Composition of Blood Plasma

Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins,...
8.1K