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Efficient Long-Range, Directional Energy Transfer through DNA-Templated Dye Aggregates.

Xu Zhou1,2, Sarthak Mandal3,4, Shuoxing Jiang1

  • 1Center for Molecular Design and Biomimetics at the Biodesign Institute , Arizona State University , Tempe , Arizona 85287 , United States.

Journal of the American Chemical Society
|April 23, 2019
PubMed
Summary
This summary is machine-generated.

Benzothiazole cyanine dye K21 forms DNA aggregates with strong excitonic coupling. These DNA-templated dye aggregates show efficient energy transfer, enabling long "wires" for light-harvesting in photonic systems.

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Area of Science:

  • Photonic Systems
  • Molecular Biophysics
  • Nanotechnology

Background:

  • Benzothiazole cyanine dye K21 forms aggregates on double-stranded DNA (dsDNA).
  • These aggregates exhibit red-shifted absorption, enhanced fluorescence, and longer fluorescence lifetime due to strong excitonic coupling.
  • Aggregate formation is weakly sequence-dependent, allowing adaptability to various DNA nanostructures.

Purpose of the Study:

  • To investigate the energy transfer efficiency through DNA-templated K21 dye aggregates.
  • To characterize the properties of K21 aggregates on dsDNA.
  • To assess the potential of these aggregates as energy transfer wires for light-harvesting applications.

Main Methods:

  • Formation of K21 dye aggregates on dsDNA templates.
  • Construction of donor-bridge-acceptor (D-B-A) complexes using Alexa Fluor 350 (donor), K21 aggregate on DNA (bridge), and Alexa Fluor 555 (acceptor).
  • Measurement of energy transfer efficiency and energy loss at different lengths of the DNA-templated aggregate bridge.

Main Results:

  • D-B-A complexes showed an overall donor-to-acceptor energy transfer efficiency of approximately 60%.
  • Energy loss was predominantly at the donor-bridge junction (63%), with minimal loss through the aggregate bridge.
  • Energy transfer efficiency from the aggregate to the acceptor was high (~96%).
  • Energy loss per nanometer through the K21 aggregate bridge was less than 1% for lengths up to 32 nm.

Conclusions:

  • DNA-templated K21 dye aggregates are efficient energy transfer bridges.
  • Minimal energy loss along the aggregate suggests potential for constructing long energy transfer wires.
  • These findings support the use of K21/DNA systems for light-harvesting applications in photonic systems.