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Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
Published on: January 17, 2019
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Post-assembly Modification of Phosphine Cages Controls Host-Guest Behavior.
Charlie T McTernan1, Tanya K Ronson1, Jonathan R Nitschke1
1Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.
Journal of the American Chemical Society
|April 23, 2019
Summary
Researchers developed a new supramolecular cage with tunable anion binding. Modifications to the cage
Area of Science:
- Supramolecular Chemistry
- Materials Science
Background:
- Supramolecular cages are versatile molecular hosts.
- Controlling guest binding is crucial for applications.
Purpose of the Study:
- To design and synthesize a novel phosphine-paneled supramolecular cage.
- To investigate post-assembly modification strategies for tuning anion binding properties.
Main Methods:
- Synthesis of a phosphine-paneled supramolecular cage framework.
- In situ post-assembly modification via oxidation, methylation, and auration.
- Evaluation of anion binding properties before and after modification.
Main Results:
- Successful synthesis of the target supramolecular cage.
- Demonstrated feasibility of in situ covalent and coordinative modifications.
- Showcased significant influence of modifications on anion binding characteristics.
Conclusions:
- The phosphine-paneled supramolecular cage offers a platform for tunable anion recognition.
- Post-assembly functionalization provides a rational approach to modify host-guest interactions.
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