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Updated: Jan 26, 2026

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
Published on: August 26, 2025
Therapeutic strategy of central vein perforation accompanied by a mediastinal lesion after catheterization
Chi-Chang Li1, Wei Zhang1, Xing-Jie Wu1
1Cardiovascular Department, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Insights
Central vein perforation during catheterization is rare. A novel percutaneous thrombin injection and balloon dilatation technique successfully treated a patient with this complication, offering a new therapeutic option.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Nephrology
Background:
- Central vein perforation is a rare but serious complication during central venous catheterization, particularly in patients requiring hemodialysis.
- Chronic kidney disease necessitates long-term hemodialysis, increasing the risk of vascular access procedures and associated complications.
Observation:
- A 50-year-old woman undergoing hemodialysis experienced central vein injury during attempted double-channel catheter placement.
- Imaging revealed catheter perforation of the central vein into the mediastinum.
Findings:
- A multidisciplinary team opted for a minimally invasive approach: percutaneous catheter thrombin injection followed by fluoroscopically guided balloon dilatation.
- This combined technique successfully sealed the central vein perforation.
Implications:
- This case highlights a successful endovascular management strategy for central vein perforation, a potentially life-threatening complication.
- The findings suggest that percutaneous thrombin injection and balloon dilatation can be an effective alternative to surgical repair in select cases.
- Further research into endovascular techniques for managing central venous injuries is warranted.
Abstract:
Central vein perforation associated with a mediastinal lesion is a rare complication of catheterization. A 50-year-old woman was diagnosed with chronic kidney disease and required hemodialysis treatment. The patient developed central vein injury during attempted placement of a double-channel catheter. A computed tomographic scan and venography showed that the catheter had punctured the mediastinum from the central vein. After comprehensive assessment and multidisciplinary consultation, percutaneous catheter thrombin injection with follow-up balloon dilatation under fluoroscopy guidance successfully fixed the perforation. We summarize the therapeutic strategy of this complication and other treatment options, and discuss the related literature of central vein injury.
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