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Hepatitis C virus infection and risk of coronary artery disease: A meta-analysis
Dan Wen1, Xin Du1, Jian-Zeng Dong1
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.
Insights
Hepatitis C virus (HCV) infection is linked to an increased risk of coronary artery disease (CAD). This meta-analysis confirms HCV as a significant risk factor for developing CAD, impacting cardiovascular health.
Area of Science:
- Infectious Diseases
- Cardiology
- Epidemiology
Background:
- Recent studies suggest a link between Hepatitis C Virus (HCV) infection and Coronary Artery Disease (CAD).
- Conflicting evidence exists regarding the association between HCV infection and CAD.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between HCV infection and CAD.
- To consolidate evidence from multiple studies to determine the risk posed by HCV infection for CAD.
Main Methods:
- Systematic literature search of PubMed, Embase, and Cochrane Library databases.
- Data extraction by two independent reviewers.
- Pooled analysis of odds ratio (OR) and relative risk (RR) using fixed and random effects models.
Main Results:
- Analysis included eight cohort studies and six case-control/cross-sectional studies.
- Cohort studies showed a pooled RR of 1.25 (95% CI: 1.12-1.40) for CAD in HCV-infected individuals.
- Case-control and cross-sectional studies indicated an OR of 1.94 (95% CI: 1.58-2.38) for CAD associated with HCV infection.
Conclusions:
- Hepatitis C Virus infection is identified as a significant risk factor for Coronary Artery Disease.
- The findings support a causal relationship between HCV and the development of CAD.
Background:
A few recent studies have demonstrated that hepatitis C virus (HCV) infection was associated with coronary artery diseases (CAD). However, there still existed studies did not confirm this correlation.
Objective:
The objective of this study was to evaluate the association between HCV infection and CAD using a meta-analysis.
Methods:
Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) and relative risk (RR) with 95% confidence interval (CI) were calculated using the fixed and random effects models.
Results:
Eight cohort studies and six case-control and cross-sectional studies were enrolled in this meta-analysis. In the cohort studies, the overall RR and 95% CIs of HCV infection for CAD was 1.25, 1.12-1.40 in random effects model. For the case-control and cross-sectional studies, the overall OR and 95% CIs of HCV infection for CAD were 1.94, 1.58-2.38 in fixed effects model. No publication bias was found in this meta-analysis.
Conclusions:
This meta-analysis showed that HCV infection was a risk factor for CAD.
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