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Related Concept Videos

Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

936
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
936
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

1.1K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
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Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

487
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
487
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

822
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
822
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

3.2K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.2K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

757
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Updated: Jan 26, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
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Acute heart failure.

Lauren Sinnenberg1, Michael M Givertz2

  • 1Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.

Trends in Cardiovascular Medicine
|April 23, 2019
PubMed
Summary
This summary is machine-generated.

Acute heart failure (AHF) presents significant mortality risks and diagnostic challenges. This review covers new developments in AHF management, including novel treatments and patient engagement strategies.

Keywords:
Acute heart failureCongestionDiureticsReadmissionVasodilators

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Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
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Area of Science:

  • Cardiology
  • Emergency Medicine
  • Critical Care

Background:

  • Acute heart failure (AHF) is a leading cause of hospitalization with high mortality rates.
  • Evidence guiding AHF diagnosis, risk stratification, and management is less robust than for chronic heart failure.
  • Current treatment paradigms for AHF require continuous updates due to evolving research.

Purpose of the Study:

  • To provide a state-of-the-art review of recent advancements in acute heart failure.
  • To summarize new developments in the diagnosis and management of AHF.
  • To highlight emerging areas of research and potential future strategies in AHF care.

Main Methods:

  • Comprehensive literature search of recent studies on acute heart failure.
  • Synthesis of current evidence on diagnosis, risk stratification, and management.
  • Identification of novel therapeutic agents and alternative care models.

Main Results:

  • Review of novel vasoactive agents showing promise in AHF treatment.
  • Exploration of alternative hospital admission models for AHF patients.
  • Discussion of strategies to enhance patient engagement in AHF management.

Conclusions:

  • Significant progress is being made in understanding and managing AHF.
  • Novel therapies and innovative care delivery models are emerging.
  • Improving patient engagement is crucial for optimizing AHF outcomes.