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A predictive computational model to estimate myocardial temperature during intracoronary hypothermia in acute

Bettine G van Willigen1, Luuk C Otterspoor2, Marcel van 't Veer3

  • 1Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands.

Medical Engineering & Physics
|April 23, 2019
PubMed

Insights

Intracoronary hypothermia using cold saline effectively cools the heart muscle during acute myocardial infarction (AMI). A new model predicts cooling to optimize this life-saving treatment for patients.

Area of Science:

  • Cardiovascular Research
  • Medical Engineering
  • Computational Biology

Background:

  • Systemic hypothermia reduces infarct size in animal models of acute myocardial infarction (AMI).
  • Clinical translation of hypothermia for AMI has been limited by delayed cooling of the myocardium.
  • Intracoronary hypothermia offers a localized and potentially faster cooling method.

Purpose of the Study:

  • To develop and validate a mathematical model for myocardial cooling via intracoronary hypothermia.
  • To support a clinically applicable method for delivering targeted hypothermia to the infarct area.
  • To predict patient-specific parameters for achieving therapeutic myocardial temperatures.

Main Methods:

  • Development of a lumped parameter model to simulate myocardial temperature dynamics.
  • Mathematical description of heat exchange between infused cold saline, blood, and myocardium.
  • Validation of the model using an isolated porcine heart model and patient data from AMI cases.

Main Results:

  • The model accurately predicts myocardial temperature changes over time.
  • It correlates cooling with intracoronary saline temperature and flow rate.
  • The model demonstrates potential for guiding clinical application of intracoronary hypothermia.

Conclusions:

  • A computational model can effectively predict myocardial temperature during intracoronary hypothermia.
  • This model may serve as an assistive tool for optimizing hypothermia treatment in acute myocardial infarction.
  • Personalized adjustments in saline flow and temperature can enhance therapeutic hypothermia efficacy.

Keywords:
Acute myocardial infarctionLumpedMyocardial hypothermiaParameter model

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