Teratogenesis of dexamethasone and preventive effect of vitamin B12

Ddy mice which were treated with 0.32 mg of dexamethasone were used. Vitamin B12 was injected subcutaneously into the animals from the 10th day to the 13th day with a dosage of 0.1r, 1r, or 10r. The rate of incidence of cleft palate was decreased to 77.0% in the 0.1r group, 58.1% in the 1r group and 67.9% in the 10r group as compared to the control value of 88.5%.