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Adverse effects of chronic treatment with the Main subclasses of highly active antiretroviral therapy: a systematic

B F Silva1, Gml Peixoto2, S R da Luz1

  • 1Adipose Tissue Research Group, Department of Physiological Sciences, State University of Maringá, Maringá, Brazil.

HIV Medicine
|April 23, 2019
PubMed

Insights

Chronic use of highly active antiretroviral therapy (HAART) can lead to adverse effects, including anemia and altered blood lipids. Individual patient factors also influence these treatment side effects.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Highly active antiretroviral therapy (HAART) is crucial for managing HIV/AIDS.
  • Understanding the long-term adverse effects of different HAART subclasses is essential for patient care.

Purpose of the Study:

  • To systematically review and elucidate the adverse effects associated with chronic treatment using the main subclasses of HAART.
  • To identify common biochemical changes and adverse events linked to specific HAART drug classes.

Main Methods:

  • A systematic review adhering to PRISMA-P guidelines was conducted.
  • Searches of major databases (MEDLINE, SCIELO, Web of Science, LILACS) were performed from January to October 2018.
  • Articles focusing on nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), and other antiretrovirals were selected.

Main Results:

  • Twenty-one articles involving 5626 participants were analyzed.
  • Common adverse effects included anemia and plasma lipid alterations with prolonged use of NRTIs, NNRTIs, and PIs.
  • Individual biological differences were linked to variations in adverse effects and treatment outcomes.

Conclusions:

  • All HAART subclasses, as well as certain drug combinations, were associated with adverse effects during chronic use.
  • Awareness of these potential side effects is critical for optimizing HIV treatment and patient management.
Abstract

Keywords:
AIDSHIVadverse effectsantiretroviral therapybloodtreatment

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